Francis de Zegher Selected Research

Leukotriene B4

1/2022

A disease-associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer.

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Francis de Zegher Research Topics

Disease

39	Insulin Resistance 02/2024 - 01/2002
20	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 05/2024 - 02/2002
15	Birth Weight (Birth Weights) 01/2017 - 01/2002
14	Obesity 06/2023 - 07/2005
11	Hirsutism 09/2023 - 06/2003
10	Hyperandrogenism 07/2010 - 06/2003
9	Weight Gain 03/2023 - 06/2004
9	Inflammation (Inflammations) 01/2022 - 04/2004
8	Hyperinsulinism (Hyperinsulinemia) 01/2019 - 01/2002
7	Body Weight (Weight, Body) 01/2023 - 06/2003
5	Acne Vulgaris 01/2023 - 11/2011
5	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019 - 10/2007
4	Type 2 Diabetes Mellitus (MODY) 01/2023 - 08/2007
4	Overweight 01/2021 - 10/2009
4	Oligomenorrhea 05/2020 - 06/2003
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 12/2003
4	Hyperglycemia 06/2015 - 10/2008
4	Pseudopseudohypoparathyroidism 04/2012 - 12/2008
4	Pseudohypoparathyroidism 01/2012 - 12/2008
3	Menstruation Disturbances 01/2023 - 01/2014
3	Infertility (Sterility) 10/2017 - 05/2013
2	Metabolic Diseases (Metabolic Disease) 01/2023 - 09/2007
2	Hypertriglyceridemia 06/2015 - 04/2004
2	Hypoadiponectinemia 07/2012 - 10/2009
2	Muscular Diseases (Myopathy) 02/2010 - 03/2004
2	Dyslipidemias (Dyslipidemia) 01/2004 - 06/2003
1	Atherosclerosis 01/2024
1	Tuberculoma 03/2023
1	Simpson-Golabi-Behmel syndrome 01/2023
1	Gonadoblastoma 02/2022
1	Dysgerminoma 02/2022
1	Neoplasms (Cancer) 02/2022
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022
1	Arthritis (Polyarthritis) 01/2022
1	Asthma (Bronchial Asthma) 01/2022
1	Muscle Weakness 01/2022
1	Precocious Puberty 01/2021
1	Sotos Syndrome 12/2020
1	Abdominal Obesity 05/2020
1	Genetic Predisposition to Disease (Genetic Predisposition) 05/2020

Drug/Important Bio-Agent (IBA)

31	Metformin (Glucophage)FDA LinkGeneric 01/2024 - 01/2003
25	Insulin (Novolin)FDA Link 01/2024 - 01/2002
22	AndrogensIBA 05/2024 - 06/2003
17	LipidsIBA 09/2023 - 06/2003
13	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 01/2002
12	Flutamide (Eulexin)FDA LinkGeneric 06/2015 - 01/2003
11	AdiponectinIBA 01/2023 - 04/2004
8	Insulin-Like Growth Factor I (IGF-1)IBA 03/2023 - 01/2002
8	C-Reactive ProteinIBA 01/2023 - 02/2006
7	Growth Hormone (Somatotropin)IBA 03/2023 - 01/2002
6	Pioglitazone (Actos)FDA Link 09/2023 - 06/2015
6	Hormones (Hormone)IBA 03/2023 - 06/2007
6	Triglycerides (Triacylglycerol)IBA 01/2023 - 09/2007
5	Spironolactone (Aldactone)FDA LinkGeneric 09/2023 - 01/2018
5	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2023 - 01/2005
4	Contraceptive Agents (Contraceptives)IBA 05/2024 - 02/2006
4	Oral ContraceptivesIBA 01/2021 - 01/2003
4	LeptinIBA 10/2012 - 06/2006
3	Testosterone (Sustanon)FDA Link 01/2023 - 05/2007
3	Proteins (Proteins, Gene)FDA Link 01/2023 - 03/2016
3	Interleukin-6 (Interleukin 6)IBA 01/2018 - 04/2004
3	Alanine Transaminase (SGPT)IBA 06/2014 - 07/2005
3	5-phenylpent-4-enyl-1-hydroperoxideIBA 04/2012 - 12/2008
3	Dehydroepiandrosterone SulfateIBA 10/2009 - 06/2004
3	drospirenone FDA LinkGeneric 02/2006 - 04/2004
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2024 - 06/2023
2	FollistatinIBA 01/2023 - 11/2011
2	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2017
2	Thyroxine (Levothyroxine)FDA LinkGeneric 01/2023 - 07/2012
2	Growth Differentiation Factor 15IBA 01/2022 - 01/2021
2	GlucocorticoidsIBA 01/2018 - 03/2005
2	C-PeptideIBA 04/2016 - 09/2013
2	GonadotropinsIBA 01/2016 - 01/2014
2	AdipokinesIBA 06/2014 - 04/2004
2	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 06/2014 - 05/2007
2	OsteocalcinIBA 03/2014 - 07/2008
2	Estradiol (Delestrogen)FDA LinkGeneric 01/2014 - 11/2006
2	Parathyroid Hormone (Parathormone)IBA 01/2012 - 12/2010
2	Androgen Receptors (Androgen Receptor)IBA 12/2010 - 05/2007
2	Sex Hormone-Binding GlobulinIBA 10/2009 - 01/2006
2	Plasminogen Activators (Plasminogen Activator)IBA 10/2007 - 02/2002
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 05/2007 - 07/2005
2	ProinsulinIBA 01/2002 - 01/2002
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 06/2023
1	Peptide Hormones (Polypeptide Hormones)IBA 01/2023
1	ProgranulinsIBA 01/2023
1	SecretagoguesIBA 01/2023
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2022
1	Leukotriene B4IBA 01/2022
1	5-methoxy-methylindoleacetic acid (DBI)IBA 11/2021
1	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/2021
1	Immunoglobulin G (IgG)IBA 01/2021
1	Immunoglobulin A (IgA)IBA 01/2021
1	A-Form DNA (A-DNA)IBA 12/2020
1	Indicators and Reagents (Reagents)IBA 01/2020
1	ChemokinesIBA 01/2020

Therapy/Procedure

16	Therapeutics 03/2023 - 01/2002
3	Contraception (Birth Control) 01/2018 - 09/2005
2	Estrogen Replacement Therapy 02/2022 - 01/2016
1	Castration 02/2022